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About This Webite
A tyrosine kinase inhibitor that goes after the EGFR - epidermal growth factor receptor - Gefitinib is classified as a tyrosine kinase inhibitor.
A recent Chinese study found Gefitinib was well tolerated in patients with Stage 4 non-small cell lung cancer, although the success rate was not particularly good. No drugs have good success against advanced lung cancer. An Italian study has likewise found gefitinib is more effective against NSCLC than carboplatin-paclitaxel.
Scheduling of paclitaxel and gefitinib to inhibit repopulation for optimal treatment of human cancer cells and xenografts that overexpress the epidermal growth factor receptor.
CAUSES OF CANCER
Researchers and scientists have identified a variety of factors that can lead to the development of cancer. If you can avoid these risk factors, it will significantly affect your chances of developing cancer.
Explained below are some of the primary risk factors:
Alcohol consumption has been associated with an increased cancer risk, especially in relation to specific types such as cancer of the oral cavity, esophagus, pharynx and larynx, liver and breast. The risk of developing cancer due to alcohol consumption is more in case of smokers.
In case you drink, it is essential that you drink in moderation. Men should limit themselves to two drinks per day whereas women should not take more than one drink per day.
The food we eat affects our chances of contracting several different types of cancers. The actual ingredients used in the meals and how they are cooked makes a difference to our cancer risks. Here are a few examples:
- Barbequed meat can be more risky in comparison to meat that may have been cooked by boiling or baking.
- Cured meats that contain compounds such as nitrosamines.
- Foods that have high amounts of saturated fat. Researchers have some evidence to suggest that people with a high-fat diet have an increased risk of cancer in comparison to people with a low-fat diet.
Cancer risks may also increase in case you are not getting sufficient amount of certain foods. Having a diet rich in vegetables, fruits, whole grains and other types of plant-based foods has been known to reduce cancer risks.
A variety of environmental factors have been known to induce development of cancer. Here are some examples:
Asbestos that was earlier used in insulation products has been associated with two forms of lung cancer. The risks are 90 times more in people who smoke and have undergone significant asbestos exposure.
Handling aromatic amines that are used in certain industrial materials has been known to induce development of bladder cancer.
Benzenes found in glue and varnish has been known to increase leukemia risks.
Certain cancers have a tendency to aggregate within families. Cancer risks are more for close relatives of an individual who has been diagnosed with a specific type of cancer. Most of these cases are related to genetic vulnerabilities. There's also the possibility that family members may be getting exposed to environmental carcinogens, for example, cigarette smoke or pollutants present in a specific geographic area. Anyone with a family history of breast, colon, prostate or ovarian cancer must undergo appropriate screening for early diagnosis.
Lack of or insufficient amount of physical activity has been associated with an increased risk of colon cancer. Research studies have indicated that individuals who exercise regularly are less likely to contract breast or colon cancer.
One theory is that exercise stimulates intestinal contractions (peristalsis). This speeds up the movement of stools in the intestine and their removal from the body. As a result, cells in the colon are less likely to be exposed to potential carcinogens present in the stools.
Smoking has been linked to around 30% of all cancer related mortalities in the U.S. It has also been identified as the primary cause for around 85% of mortalities arising out of lung cancer. Smoking has also been linked to other forms of cancer such as cancers of the head and neck, oral cavity cancers, bladder cancer, pancreatic cancer and esophageal cancer. For instance, around 50% of bladder cancer patients either smoke or used to do so earlier.
The only way to prevent risks associated with smoking is to quit completely. The risk of developing cancer decreases after an individual quits smoking. Every year thereafter, the risks continue to decrease.
The sun's rays contain ultraviolet radiation and exposure to the same has been linked to almost all occurrences of basal cell carcinoma and also squamous cell carcinoma. It is also a primary cause of malignant melanoma. Preventive measures that work best would include wearing protective clothing (such as a hat to protect the back of your neck), avoiding exposure to direct sunlight between 10 AM to 3 PM, and applying an effective sunscreen (with Sun Protection Factor (SPF) 15 or more). Wear sunglasses that can filter out ultraviolet rays. Avoid using tanning booths.
VIRUSES AND OTHER INFECTIONS
Several types of cancers are also induced due to infectious agents. These agents include parasites, certain types of viruses (for example the human papillomavirus and those that lead to hepatitis) and bacterium such as the Helicobacter that causes ulcers.
A trial of gefitinib on Ewing's Sacroma did not show that type of cancer responded to the drug.
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